Clinical observation of minocycline hydrochloride ointment combined with tinidazolein the treatment of periodontitis
盐酸米诺环素软膏联合替硝唑对牙周炎治疗的临床效果观察

摘要

目的 研究盐酸米诺环素软膏联合替硝唑对牙周炎治疗的临床效。方法 选择2021年05月-2022年05月到本院治疗牙周炎患者共76例作为观察对象，随机分为实验和对照两组，分析不同治疗效果。结果 实验组治疗有效率37/38（97.37%）更高，P＜0.05；治疗前，两组牙周牙髓相关指标（PPD、CAL、PLI）、VAS评分对比，P＞0.05；治疗后，实验组牙周牙髓相关指标优于对照组，P＜0.05；治疗2个月、3个月后实验组VAS评分低于对照组，P＜0.05；实验组龈沟液中血清指标优于对照组，P＜0.05。结论 运用盐酸米诺环素软膏联合替硝唑疗法对牙周炎治疗，安全性和疗效较高，值得运用。

Abstract

Objective To study the clinical efficacy of minocycline hydrochloride ointment combined with tinidazole in the treatment of periodontitis.
Methods A total of 76 patients with periodontitis who were treated in our hospital from May 2021 to May 2022 were selected as the observation objects. They were randomly divided into two groups: the experimental group and the control group. The different therapeutic effects were analyzed.
Results The effective rate of the experimental group was 37/38 (97.37%) higher, P<0.05; Before treatment, the scores of periodontal pulp related indicators (PPD, CAL, PLI) and VAS in the two groups were compared, P>0.05; After treatment, the relevant indexes of periodontal pulp in the experimental group were better than those in the control group (P<0.05); After 2 and 3 months of treatment, the VAS score of the experimental group was lower than that of the control group (P<0.05); The serum indexes of gingival crevicular fluid in the experimental group were better than those in the control group (P<0.05).
Conclusion   The combination of minocycline hydrochloride ointment and tinidazole is safe and effective in the treatment of periodontitis.